Study of the effects of progesterone therapy on the stilboestrol-induced sensitivity of isolated uteri of hypophysectomized rats

摘要

1. In intact rats progesterone (50 mg/kg) antagonized the effect of stilboestrol (100 μg/kg) on the vaginal smears and the uterine sensitivity. The uterine sensitivity to acetylcholine, oxytocin and 5-hydroxytryptamine was decreased by 6·8, 64 and 14·8 times, respectively, as compared with uteri removed after stilboestrol injections.